Q: Does "Word of Misery" cause a hero to suffer 1 fatigue for each damage suffered?
A: No, "Word of Misery" causes a hero to suffer 1 fatigue each time he would suffer any amount of damage. For example, if a hero suffers 3 damage, he would suffer 1 fatigue in addition to the 3 damage he suffered.
Q: Regarding Familiars: According to rules, only 3 effects can affect Characters Treated As Heroes: monster attacks, hero abilities, and Overlord cards that target a hero. What about overlord cards: Word of Misery, Word of Pain, Word of Despair, Diabolic Power? Do they affect something treated like a hero?
A: Word of Misery, Pain, Despair, all yes. Diabolic Power could be quite devastating to a group of NPCs, but affirmative to that as well.
Source Justin Kemppainen, Creative Content Developer, Fantasy Flight Games